index.html 33.2 KB
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 728 729 730 731 732 733 734 735 736 737 738 739 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 757 758 759 760 761 762 763 764 765 766 767 768 769 770 771 772 773 774 775 776 777 778 779 780 781 782 783 784 785 786 787 788 789 790 791 792 793 794 795 796 797 798 799 800 801 802 803 804 805 806 807 808 809 810 811 812 813 814 815 816 817 818 819 820 821
<!DOCTYPE html>
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>

<meta charset="utf-8">
<meta name="generator" content="quarto-1.4.232">

<meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">

<meta name="dcterms.date" content="2024-04-15">
<meta name="description" content="<p>This book will teach you how to use analycyte app, with report output examples. You’ll learn how to install app, load your data, launch analysis and interpete it.</p>">

<title>AnalyCyte: Simplify Your Post-Analysis Reporting for Cytometry</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
div.columns{display: flex; gap: min(4vw, 1.5em);}
div.column{flex: auto; overflow-x: auto;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
ul.task-list li input[type="checkbox"] {
  width: 0.8em;
  margin: 0 0.8em 0.2em -1em; /* quarto-specific, see https://github.com/quarto-dev/quarto-cli/issues/4556 */ 
  vertical-align: middle;
}
</style>


<script src="site_libs/quarto-nav/quarto-nav.js"></script>
<script src="site_libs/quarto-nav/headroom.min.js"></script>
<script src="site_libs/clipboard/clipboard.min.js"></script>
<script src="site_libs/quarto-search/autocomplete.umd.js"></script>
<script src="site_libs/quarto-search/fuse.min.js"></script>
<script src="site_libs/quarto-search/quarto-search.js"></script>
<meta name="quarto:offset" content="./">
<script src="site_libs/quarto-html/quarto.js"></script>
<script src="site_libs/quarto-html/popper.min.js"></script>
<script src="site_libs/quarto-html/tippy.umd.min.js"></script>
<script src="site_libs/quarto-html/anchor.min.js"></script>
<link href="site_libs/quarto-html/tippy.css" rel="stylesheet">
<link href="site_libs/quarto-html/quarto-syntax-highlighting.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-text-highlighting-styles">
<link href="site_libs/quarto-html/quarto-syntax-highlighting-dark.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-text-highlighting-styles">
<script src="site_libs/bootstrap/bootstrap.min.js"></script>
<link href="site_libs/bootstrap/bootstrap-icons.css" rel="stylesheet">
<link href="site_libs/bootstrap/bootstrap.min.css" rel="stylesheet" class="quarto-color-scheme" id="quarto-bootstrap" data-mode="light">
<link href="site_libs/bootstrap/bootstrap-dark.min.css" rel="prefetch" class="quarto-color-scheme quarto-color-alternate" id="quarto-bootstrap" data-mode="dark">
<script id="quarto-search-options" type="application/json">{
  "location": "sidebar",
  "copy-button": false,
  "collapse-after": 3,
  "panel-placement": "start",
  "type": "textbox",
  "limit": 20,
  "keyboard-shortcut": [
    "f",
    "/",
    "s"
  ],
  "language": {
    "search-no-results-text": "No results",
    "search-matching-documents-text": "matching documents",
    "search-copy-link-title": "Copy link to search",
    "search-hide-matches-text": "Hide additional matches",
    "search-more-match-text": "more match in this document",
    "search-more-matches-text": "more matches in this document",
    "search-clear-button-title": "Clear",
    "search-detached-cancel-button-title": "Cancel",
    "search-submit-button-title": "Submit",
    "search-label": "Search"
  }
}</script>


<link rel="stylesheet" href="custom.css">
</head>

<body class="nav-sidebar floating">

<div id="quarto-search-results"></div>
  <header id="quarto-header" class="headroom fixed-top">
  <nav class="quarto-secondary-nav">
    <div class="container-fluid d-flex">
      <button type="button" class="quarto-btn-toggle btn" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">
        <i class="bi bi-layout-text-sidebar-reverse"></i>
      </button>
        <nav class="quarto-page-breadcrumbs" aria-label="breadcrumb"><ol class="breadcrumb"><li class="breadcrumb-item"><a href="./index.html">Welcome</a></li></ol></nav>
        <a class="flex-grow-1" role="button" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass" aria-controls="quarto-sidebar" aria-expanded="false" aria-label="Toggle sidebar navigation" onclick="if (window.quartoToggleHeadroom) { window.quartoToggleHeadroom(); }">      
        </a>
      <button type="button" class="btn quarto-search-button" aria-label="" onclick="window.quartoOpenSearch();">
        <i class="bi bi-search"></i>
      </button>
    </div>
  </nav>
</header>
<!-- content -->
<div id="quarto-content" class="quarto-container page-columns page-rows-contents page-layout-article">
<!-- sidebar -->
  <nav id="quarto-sidebar" class="sidebar collapse collapse-horizontal sidebar-navigation floating overflow-auto">
    <div class="pt-lg-2 mt-2 text-left sidebar-header">
    <div class="sidebar-title mb-0 py-0">
      <a href="./">AnalyCyte: Simplify Your Post-Analysis Reporting for Cytometry</a> 
        <div class="sidebar-tools-main">
    <a href="https://gitcrcm.marseille.inserm.fr/lohmann/analycyte.book" rel="" title="Source Code" class="quarto-navigation-tool px-1" aria-label="Source Code"><i class="bi bi-git"></i></a>
  <a href="" class="quarto-color-scheme-toggle quarto-navigation-tool  px-1" onclick="window.quartoToggleColorScheme(); return false;" title="Toggle dark mode"><i class="bi"></i></a>
</div>
    </div>
      </div>
        <div class="mt-2 flex-shrink-0 align-items-center">
        <div class="sidebar-search">
        <div id="quarto-search" class="" title="Search"></div>
        </div>
        </div>
    <div class="sidebar-menu-container"> 
    <ul class="list-unstyled mt-1">
        <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./index.html" class="sidebar-item-text sidebar-link active">
 <span class="menu-text">Welcome</span></a>
  </div>
</li>
        <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/preface.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text">Preface</span></a>
  </div>
</li>
        <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/summary.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text">Key Features</span></a>
  </div>
</li>
        <li class="sidebar-item sidebar-item-section">
      <div class="sidebar-item-container"> 
            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true">
 <span class="menu-text">User’s Guide</span></a>
          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-1" aria-expanded="true" aria-label="Toggle section">
            <i class="bi bi-chevron-right ms-2"></i>
          </a> 
      </div>
      <ul id="quarto-sidebar-section-1" class="collapse list-unstyled sidebar-section depth1 show">  
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/install.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">1</span>&nbsp; <span class="chapter-title">Installation</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/users_how_to_start.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">2</span>&nbsp; <span class="chapter-title">How to Start</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/users_shiny_description.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">3</span>&nbsp; <span class="chapter-title">Workflow</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/users_shiny_action_list.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">4</span>&nbsp; <span class="chapter-title">Module list</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/users_shiny_file_type.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">5</span>&nbsp; <span class="chapter-title">File types terms</span></span></a>
  </div>
</li>
      </ul>
  </li>
        <li class="sidebar-item sidebar-item-section">
      <div class="sidebar-item-container"> 
            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="true">
 <span class="menu-text">Import</span></a>
          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-2" aria-expanded="true" aria-label="Toggle section">
            <i class="bi bi-chevron-right ms-2"></i>
          </a> 
      </div>
      <ul id="quarto-sidebar-section-2" class="collapse list-unstyled sidebar-section depth1 show">  
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_import_concat.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">6</span>&nbsp; <span class="chapter-title">Import Concatened FCS</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_import_feature.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">7</span>&nbsp; <span class="chapter-title">Import Features tables</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_import_rds.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">8</span>&nbsp; <span class="chapter-title">Import R files</span></span></a>
  </div>
</li>
      </ul>
  </li>
        <li class="sidebar-item sidebar-item-section">
      <div class="sidebar-item-container"> 
            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true">
 <span class="menu-text">Export</span></a>
          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-3" aria-expanded="true" aria-label="Toggle section">
            <i class="bi bi-chevron-right ms-2"></i>
          </a> 
      </div>
      <ul id="quarto-sidebar-section-3" class="collapse list-unstyled sidebar-section depth1 show">  
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_project_to_export.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">9</span>&nbsp; <span class="chapter-title">Export Analysis to disk</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_export_ph.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">10</span>&nbsp; <span class="chapter-title">Phantasus Table</span></span></a>
  </div>
</li>
      </ul>
  </li>
        <li class="sidebar-item sidebar-item-section">
      <div class="sidebar-item-container"> 
            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="true">
 <span class="menu-text">Content Exemple</span></a>
          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-4" aria-expanded="true" aria-label="Toggle section">
            <i class="bi bi-chevron-right ms-2"></i>
          </a> 
      </div>
      <ul id="quarto-sidebar-section-4" class="collapse list-unstyled sidebar-section depth1 show">  
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/html_files.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">11</span>&nbsp; <span class="chapter-title">Dataset description</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_recurrent_element.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">12</span>&nbsp; <span class="chapter-title">Recurrent element</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_qc.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">13</span>&nbsp; <span class="chapter-title">QC - control quality of features</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_da.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">14</span>&nbsp; <span class="chapter-title">DA - analyse abundancy of clusters - univar</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/sec_mod_ds.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">15</span>&nbsp; <span class="chapter-title">DS - analyse intensity of clusters - univar</span></span></a>
  </div>
</li>
      </ul>
  </li>
        <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/glossary.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text">Glossary</span></a>
  </div>
</li>
        <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/references.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text">References</span></a>
  </div>
</li>
        <li class="sidebar-item sidebar-item-section">
      <div class="sidebar-item-container"> 
            <a class="sidebar-item-text sidebar-link text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="true">
 <span class="menu-text">Appendices</span></a>
          <a class="sidebar-item-toggle text-start" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar-section-5" aria-expanded="true" aria-label="Toggle section">
            <i class="bi bi-chevron-right ms-2"></i>
          </a> 
      </div>
      <ul id="quarto-sidebar-section-5" class="collapse list-unstyled sidebar-section depth1 show">  
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/a4-sec_mod_deploy_ifb.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">A</span>&nbsp; <span class="chapter-title">Deploying with IFB</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/a1-flowjo.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">B</span>&nbsp; <span class="chapter-title">Import data from Flowjo</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/a2-omiq.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">C</span>&nbsp; <span class="chapter-title">Import data from OmiQ</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/a3-analycyte-verse.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">D</span>&nbsp; <span class="chapter-title">Analycyte-verse</span></span></a>
  </div>
</li>
          <li class="sidebar-item">
  <div class="sidebar-item-container"> 
  <a href="./qmd/a5-yaml-parameters.html" class="sidebar-item-text sidebar-link">
 <span class="menu-text"><span class="chapter-number">E</span>&nbsp; <span class="chapter-title">YAML Parameters</span></span></a>
  </div>
</li>
      </ul>
  </li>
    </ul>
    </div>
</nav>
<div id="quarto-sidebar-glass" data-bs-toggle="collapse" data-bs-target="#quarto-sidebar,#quarto-sidebar-glass"></div>
<!-- margin-sidebar -->
    <div id="quarto-margin-sidebar" class="sidebar margin-sidebar">
        <nav id="TOC" role="doc-toc" class="toc-active">
    <h2 id="toc-title">Table of contents</h2>
   
  <ul>
  <li><a href="#welcome" id="toc-welcome" class="nav-link active" data-scroll-target="#welcome">Welcome</a></li>
  </ul>
</nav>
    </div>
<!-- main -->
<main class="content" id="quarto-document-content">

<header id="title-block-header" class="quarto-title-block default">
<div class="quarto-title">
<h1 class="title">AnalyCyte: Simplify Your Post-Analysis Reporting for Cytometry</h1>
</div>



<div class="quarto-title-meta">

    
    <div>
    <div class="quarto-title-meta-heading">Published</div>
    <div class="quarto-title-meta-contents">
      <p class="date">April 15, 2024</p>
    </div>
  </div>
  
    
  </div>
  

</header>

<section id="welcome" class="level2 unnumbered">
<h2 class="unnumbered anchored" data-anchor-id="welcome">Welcome</h2>
<div class="justify">
<p>AnalyCyte is an <code>shiny application</code> designed to improve post-analysis for cytometry data and user control over this process. This tool simplifies the workflow and facilitate effective decision-making in research and clinical settings. Users can manage their analyses independently, thanks to customized, modular standardized reports.</p>
<p>The tool supports data export from <a href="https://www.omiq.ai/">OMIQ</a> and <a href="https://www.flowjo.com/">FlowJo</a>, as well as data import as Excel spreadsheets. All R objects generated by the application can be easily re-executed to incorporate more recent actions.</p>
</div>


</section>

</main> <!-- /main -->
<script id="quarto-html-after-body" type="application/javascript">
window.document.addEventListener("DOMContentLoaded", function (event) {
  const toggleBodyColorMode = (bsSheetEl) => {
    const mode = bsSheetEl.getAttribute("data-mode");
    const bodyEl = window.document.querySelector("body");
    if (mode === "dark") {
      bodyEl.classList.add("quarto-dark");
      bodyEl.classList.remove("quarto-light");
    } else {
      bodyEl.classList.add("quarto-light");
      bodyEl.classList.remove("quarto-dark");
    }
  }
  const toggleBodyColorPrimary = () => {
    const bsSheetEl = window.document.querySelector("link#quarto-bootstrap");
    if (bsSheetEl) {
      toggleBodyColorMode(bsSheetEl);
    }
  }
  toggleBodyColorPrimary();  
  const disableStylesheet = (stylesheets) => {
    for (let i=0; i < stylesheets.length; i++) {
      const stylesheet = stylesheets[i];
      stylesheet.rel = 'prefetch';
    }
  }
  const enableStylesheet = (stylesheets) => {
    for (let i=0; i < stylesheets.length; i++) {
      const stylesheet = stylesheets[i];
      stylesheet.rel = 'stylesheet';
    }
  }
  const manageTransitions = (selector, allowTransitions) => {
    const els = window.document.querySelectorAll(selector);
    for (let i=0; i < els.length; i++) {
      const el = els[i];
      if (allowTransitions) {
        el.classList.remove('notransition');
      } else {
        el.classList.add('notransition');
      }
    }
  }
  const toggleGiscusIfUsed = (isAlternate, darkModeDefault) => {
    const baseTheme = document.querySelector('#giscus-base-theme')?.value ?? 'light';
    const alternateTheme = document.querySelector('#giscus-alt-theme')?.value ?? 'dark';
    let newTheme = '';
    if(darkModeDefault) {
      newTheme = isAlternate ? baseTheme : alternateTheme;
    } else {
      newTheme = isAlternate ? alternateTheme : baseTheme;
    }
    const changeGiscusTheme = () => {
      // From: https://github.com/giscus/giscus/issues/336
      const sendMessage = (message) => {
        const iframe = document.querySelector('iframe.giscus-frame');
        if (!iframe) return;
        iframe.contentWindow.postMessage({ giscus: message }, 'https://giscus.app');
      }
      sendMessage({
        setConfig: {
          theme: newTheme
        }
      });
    }
    const isGiscussLoaded = window.document.querySelector('iframe.giscus-frame') !== null;
    if (isGiscussLoaded) {
      changeGiscusTheme();
    }
  }
  const toggleColorMode = (alternate) => {
    // Switch the stylesheets
    const alternateStylesheets = window.document.querySelectorAll('link.quarto-color-scheme.quarto-color-alternate');
    manageTransitions('#quarto-margin-sidebar .nav-link', false);
    if (alternate) {
      enableStylesheet(alternateStylesheets);
      for (const sheetNode of alternateStylesheets) {
        if (sheetNode.id === "quarto-bootstrap") {
          toggleBodyColorMode(sheetNode);
        }
      }
    } else {
      disableStylesheet(alternateStylesheets);
      toggleBodyColorPrimary();
    }
    manageTransitions('#quarto-margin-sidebar .nav-link', true);
    // Switch the toggles
    const toggles = window.document.querySelectorAll('.quarto-color-scheme-toggle');
    for (let i=0; i < toggles.length; i++) {
      const toggle = toggles[i];
      if (toggle) {
        if (alternate) {
          toggle.classList.add("alternate");     
        } else {
          toggle.classList.remove("alternate");
        }
      }
    }
    // Hack to workaround the fact that safari doesn't
    // properly recolor the scrollbar when toggling (#1455)
    if (navigator.userAgent.indexOf('Safari') > 0 && navigator.userAgent.indexOf('Chrome') == -1) {
      manageTransitions("body", false);
      window.scrollTo(0, 1);
      setTimeout(() => {
        window.scrollTo(0, 0);
        manageTransitions("body", true);
      }, 40);  
    }
  }
  const isFileUrl = () => { 
    return window.location.protocol === 'file:';
  }
  const hasAlternateSentinel = () => {  
    let styleSentinel = getColorSchemeSentinel();
    if (styleSentinel !== null) {
      return styleSentinel === "alternate";
    } else {
      return false;
    }
  }
  const setStyleSentinel = (alternate) => {
    const value = alternate ? "alternate" : "default";
    if (!isFileUrl()) {
      window.localStorage.setItem("quarto-color-scheme", value);
    } else {
      localAlternateSentinel = value;
    }
  }
  const getColorSchemeSentinel = () => {
    if (!isFileUrl()) {
      const storageValue = window.localStorage.getItem("quarto-color-scheme");
      return storageValue != null ? storageValue : localAlternateSentinel;
    } else {
      return localAlternateSentinel;
    }
  }
  const darkModeDefault = false;
  let localAlternateSentinel = darkModeDefault ? 'alternate' : 'default';
  // Dark / light mode switch
  window.quartoToggleColorScheme = () => {
    // Read the current dark / light value 
    let toAlternate = !hasAlternateSentinel();
    toggleColorMode(toAlternate);
    setStyleSentinel(toAlternate);
    toggleGiscusIfUsed(toAlternate, darkModeDefault);
  };
  // Ensure there is a toggle, if there isn't float one in the top right
  if (window.document.querySelector('.quarto-color-scheme-toggle') === null) {
    const a = window.document.createElement('a');
    a.classList.add('top-right');
    a.classList.add('quarto-color-scheme-toggle');
    a.href = "";
    a.onclick = function() { try { window.quartoToggleColorScheme(); } catch {} return false; };
    const i = window.document.createElement("i");
    i.classList.add('bi');
    a.appendChild(i);
    window.document.body.appendChild(a);
  }
  // Switch to dark mode if need be
  if (hasAlternateSentinel()) {
    toggleColorMode(true);
  } else {
    toggleColorMode(false);
  }
  const icon = "";
  const anchorJS = new window.AnchorJS();
  anchorJS.options = {
    placement: 'right',
    icon: icon
  };
  anchorJS.add('.anchored');
  const isCodeAnnotation = (el) => {
    for (const clz of el.classList) {
      if (clz.startsWith('code-annotation-')) {                     
        return true;
      }
    }
    return false;
  }
  const clipboard = new window.ClipboardJS('.code-copy-button', {
    text: function(trigger) {
      const codeEl = trigger.previousElementSibling.cloneNode(true);
      for (const childEl of codeEl.children) {
        if (isCodeAnnotation(childEl)) {
          childEl.remove();
        }
      }
      return codeEl.innerText;
    }
  });
  clipboard.on('success', function(e) {
    // button target
    const button = e.trigger;
    // don't keep focus
    button.blur();
    // flash "checked"
    button.classList.add('code-copy-button-checked');
    var currentTitle = button.getAttribute("title");
    button.setAttribute("title", "Copied!");
    let tooltip;
    if (window.bootstrap) {
      button.setAttribute("data-bs-toggle", "tooltip");
      button.setAttribute("data-bs-placement", "left");
      button.setAttribute("data-bs-title", "Copied!");
      tooltip = new bootstrap.Tooltip(button, 
        { trigger: "manual", 
          customClass: "code-copy-button-tooltip",
          offset: [0, -8]});
      tooltip.show();    
    }
    setTimeout(function() {
      if (tooltip) {
        tooltip.hide();
        button.removeAttribute("data-bs-title");
        button.removeAttribute("data-bs-toggle");
        button.removeAttribute("data-bs-placement");
      }
      button.setAttribute("title", currentTitle);
      button.classList.remove('code-copy-button-checked');
    }, 1000);
    // clear code selection
    e.clearSelection();
  });
  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
    const config = {
      allowHTML: true,
      maxWidth: 500,
      delay: 100,
      arrow: false,
      appendTo: function(el) {
          return el.parentElement;
      },
      interactive: true,
      interactiveBorder: 10,
      theme: 'quarto',
      placement: 'bottom-start',
    };
    if (contentFn) {
      config.content = contentFn;
    }
    if (onTriggerFn) {
      config.onTrigger = onTriggerFn;
    }
    if (onUntriggerFn) {
      config.onUntrigger = onUntriggerFn;
    }
    window.tippy(el, config); 
  }
  const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
  for (var i=0; i<noterefs.length; i++) {
    const ref = noterefs[i];
    tippyHover(ref, function() {
      // use id or data attribute instead here
      let href = ref.getAttribute('data-footnote-href') || ref.getAttribute('href');
      try { href = new URL(href).hash; } catch {}
      const id = href.replace(/^#\/?/, "");
      const note = window.document.getElementById(id);
      return note.innerHTML;
    });
  }
  const xrefs = window.document.querySelectorAll('a.quarto-xref');
  const processXRef = (id, note) => {
    if (id.startsWith('sec-')) {
      // Special case sections, only their first couple elements
      const container = document.createElement("div");
      if (note.children && note.children.length > 2) {
        for (let i = 0; i < 2; i++) {
          container.appendChild(note.children[i].cloneNode(true));
        }
        return container.innerHTML
      } else {
        return note.innerHTML;
      }
    } else {
      return note.innerHTML;
    }
  }
  for (var i=0; i<xrefs.length; i++) {
    const xref = xrefs[i];
    tippyHover(xref, undefined, function(instance) {
      instance.disable();
      let url = xref.getAttribute('href');
      let hash = undefined; 
      if (url.startsWith('#')) {
        hash = url;
      } else {
        try { hash = new URL(url).hash; } catch {}
      }
      if (hash) {
        const id = hash.replace(/^#\/?/, "");
        const note = window.document.getElementById(id);
        if (note !== null) {
          try {
            const html = processXRef(id, note);
            instance.setContent(html);
          } finally {
            instance.enable();
            instance.show();
          }
        } else {
          // See if we can fetch this
          fetch(url.split('#')[0])
          .then(res => res.text())
          .then(html => {
            const parser = new DOMParser();
            const htmlDoc = parser.parseFromString(html, "text/html");
            const note = htmlDoc.getElementById(id);
            if (note !== null) {
              const html = processXRef(id, note);
              instance.setContent(html);
            } 
          }).finally(() => {
            instance.enable();
            instance.show();
          });
        }
      }
    }, function(instance) {
    });
  }
      let selectedAnnoteEl;
      const selectorForAnnotation = ( cell, annotation) => {
        let cellAttr = 'data-code-cell="' + cell + '"';
        let lineAttr = 'data-code-annotation="' +  annotation + '"';
        const selector = 'span[' + cellAttr + '][' + lineAttr + ']';
        return selector;
      }
      const selectCodeLines = (annoteEl) => {
        const doc = window.document;
        const targetCell = annoteEl.getAttribute("data-target-cell");
        const targetAnnotation = annoteEl.getAttribute("data-target-annotation");
        const annoteSpan = window.document.querySelector(selectorForAnnotation(targetCell, targetAnnotation));
        const lines = annoteSpan.getAttribute("data-code-lines").split(",");
        const lineIds = lines.map((line) => {
          return targetCell + "-" + line;
        })
        let top = null;
        let height = null;
        let parent = null;
        if (lineIds.length > 0) {
            //compute the position of the single el (top and bottom and make a div)
            const el = window.document.getElementById(lineIds[0]);
            top = el.offsetTop;
            height = el.offsetHeight;
            parent = el.parentElement.parentElement;
          if (lineIds.length > 1) {
            const lastEl = window.document.getElementById(lineIds[lineIds.length - 1]);
            const bottom = lastEl.offsetTop + lastEl.offsetHeight;
            height = bottom - top;
          }
          if (top !== null && height !== null && parent !== null) {
            // cook up a div (if necessary) and position it 
            let div = window.document.getElementById("code-annotation-line-highlight");
            if (div === null) {
              div = window.document.createElement("div");
              div.setAttribute("id", "code-annotation-line-highlight");
              div.style.position = 'absolute';
              parent.appendChild(div);
            }
            div.style.top = top - 2 + "px";
            div.style.height = height + 4 + "px";
            div.style.left = 0;
            let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
            if (gutterDiv === null) {
              gutterDiv = window.document.createElement("div");
              gutterDiv.setAttribute("id", "code-annotation-line-highlight-gutter");
              gutterDiv.style.position = 'absolute';
              const codeCell = window.document.getElementById(targetCell);
              const gutter = codeCell.querySelector('.code-annotation-gutter');
              gutter.appendChild(gutterDiv);
            }
            gutterDiv.style.top = top - 2 + "px";
            gutterDiv.style.height = height + 4 + "px";
          }
          selectedAnnoteEl = annoteEl;
        }
      };
      const unselectCodeLines = () => {
        const elementsIds = ["code-annotation-line-highlight", "code-annotation-line-highlight-gutter"];
        elementsIds.forEach((elId) => {
          const div = window.document.getElementById(elId);
          if (div) {
            div.remove();
          }
        });
        selectedAnnoteEl = undefined;
      };
      // Attach click handler to the DT
      const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
      for (const annoteDlNode of annoteDls) {
        annoteDlNode.addEventListener('click', (event) => {
          const clickedEl = event.target;
          if (clickedEl !== selectedAnnoteEl) {
            unselectCodeLines();
            const activeEl = window.document.querySelector('dt[data-target-cell].code-annotation-active');
            if (activeEl) {
              activeEl.classList.remove('code-annotation-active');
            }
            selectCodeLines(clickedEl);
            clickedEl.classList.add('code-annotation-active');
          } else {
            // Unselect the line
            unselectCodeLines();
            clickedEl.classList.remove('code-annotation-active');
          }
        });
      }
  const findCites = (el) => {
    const parentEl = el.parentElement;
    if (parentEl) {
      const cites = parentEl.dataset.cites;
      if (cites) {
        return {
          el,
          cites: cites.split(' ')
        };
      } else {
        return findCites(el.parentElement)
      }
    } else {
      return undefined;
    }
  };
  var bibliorefs = window.document.querySelectorAll('a[role="doc-biblioref"]');
  for (var i=0; i<bibliorefs.length; i++) {
    const ref = bibliorefs[i];
    const citeInfo = findCites(ref);
    if (citeInfo) {
      tippyHover(citeInfo.el, function() {
        var popup = window.document.createElement('div');
        citeInfo.cites.forEach(function(cite) {
          var citeDiv = window.document.createElement('div');
          citeDiv.classList.add('hanging-indent');
          citeDiv.classList.add('csl-entry');
          var biblioDiv = window.document.getElementById('ref-' + cite);
          if (biblioDiv) {
            citeDiv.innerHTML = biblioDiv.innerHTML;
          }
          popup.appendChild(citeDiv);
        });
        return popup.innerHTML;
      });
    }
  }
});
</script>
</div> <!-- /content -->




</body></html>